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Indian J Hum Genet. 2011 Sep;17(3):132-44. doi: 10.4103/0971-6866.92087.

A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer.

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  • 1Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, Republic of South Africa.


Cervical cancer is the second most common cancer in women worldwide. This is caused by oncogenic types of human papillomavirus (HPV) infection. Although large numbers of young sexually active women get HPV-infected, only a small fraction develop cervical cancer. This points to different co-factors for regression of HPV infection or progression to cervical cancer. Host genetic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review is to compile the advances in the field of host genetics of cervical cancer. MEDLINE database was searched using the terms, 'HPV', 'cervical', 'CIN', 'polymorphism(s)', 'cervical'+ *the name of the gene* and 'HPV'+ *the name of the gene*. This review focuses on the major host genes reported to affect the progression to cervical cancer in HPV infected individuals.


Cervical cancer; HPV; genetics; polymorphism; progression

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