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J Leukoc Biol. 2012 Jul;92(1):75-82. doi: 10.1189/jlb.1011530. Epub 2012 Feb 17.

Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury.

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University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany.


Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.

[Indexed for MEDLINE]

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