Format

Send to

Choose Destination
See comment in PubMed Commons below
Cold Spring Harb Symp Quant Biol. 2011;76:291-8. doi: 10.1101/sqb.2012.76.010439. Epub 2012 Feb 17.

NAD+ as a signaling molecule modulating metabolism.

Author information

1
Nestlé Institute of Health Sciences, CH-1015, Lausanne, Switzerland.

Abstract

The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.

PMID:
22345172
PMCID:
PMC3616234
DOI:
10.1101/sqb.2012.76.010439
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center