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Neurosci Lett. 1990 Jul 31;115(2-3):195-200.

Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons.

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1
Department of Pharmacological Sciences, University of Chicago, IL 60637.

Abstract

When hippocampal pyramidal neurons are grown in culture they develop excitatory synaptic contacts. If these cultures are perfused with Mg2(+)-free, glycine supplemented medium the neurons exhibit fluctuations in [Ca2+]i and associated cell death ('excitotoxicity'). These phenomena involve the activation of NMDA receptors. When cultures are treated with the K(+)-channel activators cromakalim and diazoxide both the [Ca2+]i fluctuations and the neuronal death are abolished. These effects are reversed by the sulfonylurea glyburide. It thus appears that K(+)-channel activators may be a novel therapeutic intervention in epilepsy and associated disorders.

PMID:
2234498
DOI:
10.1016/0304-3940(90)90454-h
[Indexed for MEDLINE]

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