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Wiley Interdiscip Rev Syst Biol Med. 2012 May-Jun;4(3):297-309. doi: 10.1002/wsbm.1165. Epub 2012 Feb 17.

Linking genome to epigenome.

Author information

1
Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA. gcyuan@jimmy.harvard.edu

Abstract

Recent epigenomic studies have identified significant differences between developmental stages and cell types. While the importance of epigenetic regulation has been increasingly recognized, it remains unclear how the global epigenetic patterns are established and maintained. Here I review a number of recent studies with the emphasis on the role of the genomic sequence in shaping the epigenetic landscape. These studies strongly suggest that the sequence information is important not just for controlling target specificity but for orchestrating the diversity of epigenetic patterns among different cell types. The epigenome is maintained by the complex network of a large number of interactions. Integrative approaches are needed to gain insights into these networks.

PMID:
22344857
PMCID:
PMC3328655
DOI:
10.1002/wsbm.1165
[Indexed for MEDLINE]
Free PMC Article
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