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Sci Transl Med. 2012 Feb 15;4(121):121ps3. doi: 10.1126/scitranslmed.3003492.

Viral and inflammatory triggers of neurodegenerative diseases.

Author information

1
Harvard Medical School, Boston, MA 02115, USA.

Abstract

Here, we synthesize research behind the emerging hypothesis that inflammation--which can result, for example, from viral infections--can initiate and propagate chronic neuronal dysfunction, an event that precedes the clinical onset of many neurodegenerative diseases. Therapeutic approaches that target immunological pathways in the prodromal phase of diseases might decrease the incidence of neurodegenerative disorders and increase the therapeutic window for neuroprotection.

PMID:
22344685
PMCID:
PMC3982831
DOI:
10.1126/scitranslmed.3003492
[Indexed for MEDLINE]
Free PMC Article

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