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Nat Struct Mol Biol. 2012 Feb 19;19(3):361-3. doi: 10.1038/nsmb.2252.

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

Author information

1
Department of Biology, Stanford University, Stanford, California, USA.

Abstract

Methylation of histones is central to chromatin regulation, and thus previously unknown mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here we identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast. Set5's enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses.

PMID:
22343720
PMCID:
PMC3334815
DOI:
10.1038/nsmb.2252
[Indexed for MEDLINE]
Free PMC Article

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