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Nat Struct Mol Biol. 2012 Feb 12;19(3):355-7. doi: 10.1038/nsmb.2233.

Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog.

Author information

1
Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, USA.

Abstract

We report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes.

PMID:
22343718
PMCID:
PMC3633560
DOI:
10.1038/nsmb.2233
[Indexed for MEDLINE]
Free PMC Article

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