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Neurosurgery. 1990 Sep;27(3):418-21.

Whither short-course chemotherapy for tuberculous meningitis?

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Department of Neurosurgery Seth GS Medical College, Bombay, India.


Short-course chemotherapy is well established for the treatment of pulmonary tuberculosis but not for extrapulmonary disease. We present a series of 35 cases in which chemotherapy for tuberculous meningitis was given for a period of less than 2 years. Short-term therapy was associated with recrudescence of tuberculous meningitis and, in some cases, with the development of deep cerebral infarcts and permanent neurological deficits. We think short-term chemotherapy for tuberculosis of the central nervous system is inadequate.

[Indexed for MEDLINE]

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