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Neuroimage. 2012 Aug 15;62(2):871-80. doi: 10.1016/j.neuroimage.2012.01.133. Epub 2012 Feb 11.

The general linear model and fMRI: does love last forever?

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Neurospin, Bat. 145, CEA, Gif-sur-Yvette 91191, France.


In this review, we first set out the general linear model (GLM) for the non technical reader, as a tool able to do both linear regression and ANOVA within the same flexible framework. We present a short history of its development in the fMRI community, and describe some interesting examples of its early use. We offer a few warnings, as the GLM relies on assumptions that may not hold in all situations. We conclude with a few wishes for the future of fMRI analyses, with or without the GLM. The appendix develops some aspects of use of contrasts for testing for the more technical reader.

[Indexed for MEDLINE]

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