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Semin Cell Dev Biol. 2012 Aug;23(6):621-5. doi: 10.1016/j.semcdb.2012.02.001. Epub 2012 Feb 10.

Amino acid sensing and regulation of mTORC1.

Author information

1
School of Pharmacy, Harbin University of Commerce, Harbin, 150076, PR China. lijun.yann@hotmail.com

Abstract

Amino acids play fundamental roles in the cell both as the building blocks of new proteins and as metabolic precursors. To adapt to their limitation during periods of protein starvation, multiple adaptive mechanisms have evolved, including a rapid cessation of new protein synthesis, an increase in amino acid biosynthesis and transport, and autophagy. Here, we discuss what we currently know about how amino acid limitation is sensed, and how this sensing might be transmitted to mTORC1 to regulate protein synthesis and autophagy.

PMID:
22342805
DOI:
10.1016/j.semcdb.2012.02.001
[Indexed for MEDLINE]
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