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Curr Opin Chem Biol. 2012 Apr;16(1-2):117-23. doi: 10.1016/j.cbpa.2012.01.018. Epub 2012 Feb 16.

Combinatorial biosynthesis of polyketides--a perspective.

Author information

1
Department of Chemical Engineering, Stanford University, Stanford, CA 94305, United States.

Abstract

Since their discovery, polyketide synthases have been attractive targets of biosynthetic engineering to make 'unnatural' natural products. Although combinatorial biosynthesis has made encouraging advances over the past two decades, the field remains in its infancy. In this enzyme-centric perspective, we discuss the scientific and technological challenges that could accelerate the adoption of combinatorial biosynthesis as a method of choice for the preparation of encoded libraries of bioactive small molecules. Borrowing a page from the protein structure prediction community, we propose a periodic challenge program to vet the most promising methods in the field, and to foster the collective development of useful tools and algorithms.

PMID:
22342766
PMCID:
PMC3328608
DOI:
10.1016/j.cbpa.2012.01.018
[Indexed for MEDLINE]
Free PMC Article

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