Format

Send to

Choose Destination
See comment in PubMed Commons below
Drug Discov Today. 2012 Mar;17(5-6):188-93. doi: 10.1016/j.drudis.2012.01.025. Epub 2012 Feb 8.

Exploiting genetic complexity in cancer to improve therapeutic strategies.

Author information

1
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK. mj12@sanger.ac.uk

Abstract

Advances in genome sequencing technologies are enabling researchers to make rapid progress in defining the entire repertoire of causal genetic changes in cancer. The response of patients with cancer to therapy is often highly variable and there is an increasing number of examples where mutations in cancer genomes have been shown to have a profound effect on the clinical effectiveness of drugs. An urgent challenge for the research and clinical communities is how to translate these genomic data sets into new and improved therapeutic strategies for the treatment of patients. The use of large-scale cell line-based drug screens to identify genomic 'biomarkers' of drug response for the stratification of patients has the potential to transform how patients with cancer are treated.

PMID:
22342219
PMCID:
PMC3672976
DOI:
10.1016/j.drudis.2012.01.025
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center