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Curr Opin Immunol. 2012 Apr;24(2):146-52. doi: 10.1016/j.coi.2012.01.015. Epub 2012 Feb 16.

The role of STAT5 in lymphocyte development and transformation.

Author information

1
University of Minnesota, Center for Immunology, Masonic Cancer Center, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55455, USA.

Abstract

STAT5 plays a crucial role in B and T lymphocyte development. However, whether STAT5 primarily plays a role as a permissive factor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiation, has been unclear. In addition, while STAT5 has been suggested to act as a transcriptional repressor, the mechanism by which it represses transcription was undefined. Recent reports have begun to shed new light on these roles for STAT5 in lymphocyte development, transcriptional repression, and leukemic transformation.

PMID:
22342169
PMCID:
PMC3319496
DOI:
10.1016/j.coi.2012.01.015
[Indexed for MEDLINE]
Free PMC Article

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