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Trends Neurosci. 2012 May;35(5):274-83. doi: 10.1016/j.tins.2011.12.007. Epub 2012 Feb 14.

Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2.

Author information

1
Center for Neural Science, New York University, New York, NY 10003, USA. ca60@nyu.edu

Abstract

Life and societies would change significantly if memory capacity or persistence in health and disease could be enhanced. It has been known for many years that memory can be improved and strengthened. Substances known to enhance memory include hormones, neurotransmitters, neuropeptides and metabolic substrates. Recently, attention has been given to identifying the molecular mechanisms and targets whereby memory enhancement can be achieved. One approach would be to target the physiological changes that are induced by learning and naturally required for memory strengthening via consolidation and reconsolidation. Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).

PMID:
22341662
PMCID:
PMC3348400
DOI:
10.1016/j.tins.2011.12.007
[Indexed for MEDLINE]
Free PMC Article
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