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Cell Host Microbe. 2012 Feb 16;11(2):101-3. doi: 10.1016/j.chom.2012.01.012.

Viral FLIPping autophagy for longevity.

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Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA.


Tumor-causing γ-herpesviruses have evolved elaborate mechanisms to deal with almost every aspect of host cell defense. In this issue of Cell Host & Microbe, Leidal et al. (2012) report an oncogenic synergy between the latent KSHV proteins v-FLIP and v-cyclin during KSHV persistent infection that reshapes autophagy.

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