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Cell. 2012 Feb 17;148(4):651-63. doi: 10.1016/j.cell.2011.12.028.

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

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1
Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the setting of telomere dysfunction enabled full malignant progression with alleviation of telomere dysfunction-induced checkpoints. These cancers possessed copy number alterations targeting key loci in human T cell lymphomagenesis. Upon telomerase extinction, tumor growth eventually slowed with reinstatement of telomere dysfunction-induced checkpoints, yet growth subsequently resumed as tumors acquired alternative lengthening of telomeres (ALT) and aberrant transcriptional networks centering on mitochondrial biology and oxidative defense. ALT+ tumors acquired amplification/overexpression of PGC-1β, a master regulator of mitochondrial biogenesis and function, and they showed marked sensitivity to PGC-1β or SOD2 knockdown. Genetic modeling of telomerase extinction reveals vulnerabilities that motivate coincidental inhibition of mitochondrial maintenance and oxidative defense mechanisms to enhance antitelomerase cancer therapy.

PMID:
22341440
PMCID:
PMC3286017
DOI:
10.1016/j.cell.2011.12.028
[Indexed for MEDLINE]
Free PMC Article

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