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Am J Obstet Gynecol. 2012 Apr;206(4):358.e10-8. doi: 10.1016/j.ajog.2012.01.009. Epub 2012 Jan 13.

Haptoglobin phenotype, angiogenic factors, and preeclampsia risk.

Author information

1
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA. weissgerbertl@mwri.magee.edu

Abstract

OBJECTIVE:

We sought to determine whether haptoglobin (Hp) phenotype is related to preeclampsia risk, or to plasma concentrations of soluble endoglin (sEng), soluble fms-like tyrosine kinase 1 (sFlt-1), and placental growth factor (PlGF).

STUDY DESIGN:

Hp phenotype was retrospectively determined in primiparous women with uncomplicated pregnancies (n = 309), gestational hypertension (n = 215), and preeclampsia (n = 249). Phenotype was assessed by peroxidase staining following native polyacrylamide gel electrophoresis of hemoglobin-supplemented serum.

RESULTS:

Compared with Hp 1-1, Hp 2-1 was associated with a significantly increased risk of preeclampsia (odds ratio, 2.11; 95% confidence interval, 1.07-4.18) and term preeclampsia (odds ratio, 2.45; 95% confidence interval, 1.07-5.83) in Caucasian women. Hp phenotype was not associated with preeclampsia risk in African Americans. Preeclamptic women had higher plasma sEng and sFlt-1, and lower PlGF, than control subjects. sEng, sFlt-1, and PlGF did not differ among women of different Hp phenotypes.

CONCLUSION:

Hp 2-1 is associated with higher preeclampsia risk in primiparous Caucasian women.

PMID:
22340942
PMCID:
PMC3319170
DOI:
10.1016/j.ajog.2012.01.009
[Indexed for MEDLINE]
Free PMC Article
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