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Cancer Cell. 2012 Feb 14;21(2):150-4. doi: 10.1016/j.ccr.2012.01.001.

Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox.

Author information

1
Department of Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0864, USA. gfeng@ucsd.edu

Abstract

In delineating the molecular pathogenesis of hepatocellular carcinoma (HCC), recent experiments in mouse tumor models have revealed unexpected tumor-suppressing effects in genes previously identified as pro-oncogenic. This contradiction underscores the complexity of hepatocarcinogenesis and predicts uncertainty in targeting these molecules for HCC therapy. Deciphering the underlying mechanisms for these paradoxical functions will elucidate the complex molecular and cellular communications driving HCC development, and will also suggest more thoughtful therapeutic strategies for this deadly disease.

PMID:
22340589
PMCID:
PMC3285429
DOI:
10.1016/j.ccr.2012.01.001
[Indexed for MEDLINE]
Free PMC Article

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