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Dev Cell. 2012 Feb 14;22(2):238-9. doi: 10.1016/j.devcel.2012.01.021.

Maintaining muscle mitochondria via transsynaptic signaling.

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Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.


Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells through LAR and Robo receptor activation.

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