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Addict Biol. 2013 Sep;18(5):763-73. doi: 10.1111/j.1369-1600.2011.00433.x. Epub 2012 Feb 17.

Co-sensitivity to the incentive properties of palatable food and cocaine in rats; implications for co-morbid addictions.

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1
Department of Psychology, University of Guelph, Ontario, Canada.

Abstract

Several lines of evidence suggest that there may be a shared vulnerability to acquire behaviors motivated by strong incentive stimuli. Non-food restricted male Sprague-Dawley rats (n = 78) underwent place conditioning with Oreos, and were subsequently tested on cocaine self-administration (SA) on fixed and progressive ratios, as well as extinction and reinstatement by cocaine primes and by consumption of Oreos. Although there was a group preference for the Oreo-paired compartment, at the individual level some rats (69%) displayed a preference and others did not. In cocaine SA, 'preference' rats achieved higher break points on a progressive ratio, and displayed greater responding during extinction and cocaine-induced reinstatement. Within the context of this study, Oreo-cocaine cross-reinstatement was not observed. In a control study, rats (n = 29) conditioned with a less palatable food (rice cakes) also displayed individual differences in place preference, but not on subsequent cocaine tests. These findings indicate that there is a relationship between incentive learning promoted by palatable foods and by cocaine. This supports the hypothesis that co-morbid food-drug addictions may result from a shared vulnerability to acquire behaviors motivated by strong incentives.

KEYWORDS:

Cocaine; conditioned place preference; intravenous self-administration; palatable food; rat; reinstatement

[Indexed for MEDLINE]

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