Format

Send to

Choose Destination
Growth Factors. 2012 Apr;30(2):88-106. doi: 10.3109/08977194.2012.660936. Epub 2012 Feb 20.

Biology and significance of the JAK/STAT signalling pathways.

Author information

1
Walter & Eliza Hall Institute, 1G Royal Parade, Parkville 3052, Australia.

Abstract

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth factors has resulted in it becoming one of the most well-studied intracellular signalling networks. The field has progressed from the identification of the individual components to high-resolution crystal structures of both JAK and STAT, and an understanding of the complexities of the molecular activation and deactivation cycle which results in a diverse, yet highly specific and regulated pattern of transcriptional responses. While there is still more to learn, we now appreciate how disruption and deregulation of this pathway can result in clinical disease and look forward to adoption of the next generation of JAK inhibitors in routine clinical treatment.

PMID:
22339650
PMCID:
PMC3762697
DOI:
10.3109/08977194.2012.660936
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center