(

*a*) Raw mean intensities 〈

*I*〉 (solid squares) and 〈

*I*/σ

_{I}〉 (open squares) as a function of the uncorrected dose. Black and dashed lines: fits by exponential functions. Vertical dashed and dashed-dotted lines indicate the

*D* _{1/2} obtained with the uncorrected dose. (

*b*) Normalized quantities

*M* _{n} plotted as a function of adjusted dose. Average intensity 〈

*I*〉

_{free} (red solid squares) and 〈

*I*/σ

_{I}〉

_{free} (red open squares) are plotted as a function of adjusted dose. Red solid line: fit by a straight line. Thin dotted line: fit by an exponential function. The dashed vertical line indicates the corresponding

*D* _{1/2}. Black solid and black open triangles: variation of the mean intensity 〈

*I*〉

_{L} and 〈

*I*/σ

_{I}〉

_{L}, respectively, observed in the control experiment as a function of virtual dose. The black solid and dashed lines are fits by a straight line. (

*c*) Normalized

*R* ^{AO} values (black spheres) as a function of adjusted dose. Black dashed curve: fit by a single exponential. The horizontal/vertical dashed lines indicate

and the corresponding kinetic dose limit

. (

*d*) Red squares: relaxation times τ

_{RSV1} from the SVD analysis as a function of adjusted dose. The red dashed line is a guide to the eye. Green triangles: inverse of the rate coefficient (relaxation time τ

_{post}) obtained from posterior analysis. The green dashed line is a guide to the eye. Black spheres: difference between τ

_{post} and τ

_{RSV1}. The dashed vertical line indicates the kinetic dose limit

.