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Mutat Res. 1990 May-Jul;237(3-4):165-71.

A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans.

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Department of Molecular Biology, School of Medicine, Tokai University, Kanagawa, Japan.


A methyl viologen (paraquat)-sensitive mutant, mev-1 (LG III), in Caenorhabditis elegans was about 4 times more sensitive to methyl viologen than the wild type. This mutant was also hypersensitive to oxygen. The brood size was about 1/4 that of the wild type. The average life span was determined to be 9.3 days as compared to 14.3 days for the wild type. The activity of superoxide dismutase (SOD), a scavenging enzyme for superoxide anion, was about half the wild-type level. We suggest that oxygen radicals may be involved in the normal aging mechanism in C. elegans.

[Indexed for MEDLINE]

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