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Diabetes Care. 2012 Apr;35(4):861-7. doi: 10.2337/dc11-1971. Epub 2012 Feb 14.

The risk of a persistent glucose metabolism impairment after gestational diabetes mellitus is increased in patients with polycystic ovary syndrome.

Author information

1
Department of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it

Abstract

OBJECTIVE:

To test the hypothesis that the risk of persistent glucose impairment after gestational diabetes mellitus (GDM) is increased in patients with polycystic ovary syndrome (PCOS).

RESEARCH DESIGN AND METHODS:

The prospective case-control study included 42 pregnant patients with PCOS and GDM and 84 pregnant control patients with GDM but without clinical and biochemical hyperandrogenism, polycystic ovaries, and oligo-anovulation. The case and control subjects were matched one to two for age and BMI. The glycemic profiles were studied in all subjects 6 weeks, 12 weeks, and 18 months after delivery. The incidence and the relative risk (RR) were calculated for overall persistence of an abnormal glycemic pattern and for each specific alteration, i.e., impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM).

RESULTS:

At 18 months after delivery, the incidences of IFG, IGT, and IFG-IGT were significantly (P < 0.05) higher in the cases than in the controls. At the 18-month follow-up, the RR for the composite outcome of glucose metabolism impairment in PCOS women was 3.45 (95% CI 1.82-6.58).

CONCLUSIONS:

Patients with PCOS are at increased risk for a persistent impaired glucose metabolism after GDM.

PMID:
22338097
PMCID:
PMC3308296
DOI:
10.2337/dc11-1971
[Indexed for MEDLINE]
Free PMC Article

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