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Nature. 2012 Feb 15;482(7385):347-55. doi: 10.1038/nature10888.

The microcosmos of cancer.

Author information

1
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

Abstract

The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself.

PMID:
22337054
PMCID:
PMC3509753
DOI:
10.1038/nature10888
[Indexed for MEDLINE]
Free PMC Article

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