Format

Send to

Choose Destination
Cancer Biol Ther. 2012 Jan 1;13(1):14-24. doi: 10.4161/cbt.13.1.18869.

Tumor microenvironment and breast cancer progression: a complex scenario.

Author information

1
Department of Radiology and Medical Physics, University of Granada, Granada, Spain.

Abstract

It is now widely accepted that the development and progression of a tumor toward the malignant phenotype is highly dependent on interactions between tumor cells and the tumor microenvironment. Different components of the tumor microenvironment may have stimulatory or inhibitory effects on tumor progression by regulating the gene expression repertoire in tumor cells and stromal cells. This review analyzes novel research findings on breast cancer progression, discussing acquisition of the metastatic phenotype in breast disease in relation to different aspects of cross-talk among components of the tumor microenvironment. Knowledge of the interaction of all of these factors would contribute to elucidating the mechanisms that disrupt regulatory/signaling cascades and downstream effects in breast cancer.

PMID:
22336584
DOI:
10.4161/cbt.13.1.18869
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center