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Drug Resist Updat. 2012 Feb-Apr;15(1-2):39-49. doi: 10.1016/j.drup.2012.01.006. Epub 2012 Feb 13.

The tumor microenvironment is a dominant force in multidrug resistance.

Author information

1
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977, Berkeley, CA 94720, USA.

Abstract

The emergence of clinical drug resistance is still one of the most challenging factors in cancer treatment effectiveness. Until more recently, the assumption has been that random genetic lesions are sufficient to explain the progression of malignancy and escape from chemotherapy. Here we propose an additional perspective, one in which the tumor cells despite the malignant genome could find a microenvironment either within the tumor or as a dormant cell to remain polar and blend into an organized context. Targeting this dynamic interplay could be considered a new avenue to prevent therapeutic resistance, and may even provide a promising effective cancer treatment.

PMID:
22335920
PMCID:
PMC3658318
DOI:
10.1016/j.drup.2012.01.006
[Indexed for MEDLINE]
Free PMC Article

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