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Expert Opin Pharmacother. 2012 Mar;13(4):607-11. doi: 10.1517/14656566.2012.658772. Epub 2012 Feb 15.

The TALENT Study.

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Clinica Medica, Ospedale San Gerardo, Via Pergolesi 33, 20052 Monza (Milano), Italy.


Current guidelines on antihypertensive treatment emphasize the importance of combination drug treatment for achieving a full blood pressure control. The TALENT Study, involving more than 400 high-risk hypertensive patients, aimed to evaluate the efficacy and safety profile of nifedipine gastrointestinal therapeutic system (GITS) 20 mg/telmisartan 80 mg combination, as compared to the single monotherapies. After 8 weeks, ambulatory blood pressure values were significantly more reduced by the combination treatment than by single monotherapies. These potentiated blood-pressure-lowering effects were mirrored by a higher trough-to-peak ratio and smoothness index. They were also accompanied by: i) significantly greater blood pressure (particularly systolic) control; ii) a greater ability of combination drug treatment to achieve a controlled blood pressure at a time earlier than that found in single monotherapies; and iii) a better side-effects profile.

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