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Expert Opin Biol Ther. 2012 Apr;12(4):425-41. doi: 10.1517/14712598.2012.664128. Epub 2012 Feb 15.

Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma - targets for therapeutic intervention?

Author information

1
Tyrolean Cancer Research Institute, Innsbruck, Austria. Karin.Joehrer@tkfi.at

Abstract

INTRODUCTION:

Chemokines and their receptors play essential roles in the development, maintenance and proper functioning of the immune system. B cell-T cell interactions are modulated by chemokines. In B cell malignancies, these interactions may have tumor-promoting consequences.

AREAS COVERED:

This review summarizes physiological B cell-T cell interactions and discusses their pathological role in the onset and progression of B cell malignancies with a special focus on chronic lymphocytic leukemia and multiple myeloma. Experimental data on chemokine-guided B cell-T cell actions in B cell malignancies from murine models as well as in vitro data are summarized and their potential as future therapeutic targets is critically discussed.

EXPERT OPINION:

Direct or indirect targeting of chemokine receptors involved in localization and T-cell-dependent activation of B lymphocytes can provide strong synergisms with conventional or immunomodulatory therapies by disrupting the microenvironmental conditions necessary for survival and proliferation of malignant B lymphocytes. However, further knowledge of these interactions between B and T cells is needed.

PMID:
22332909
DOI:
10.1517/14712598.2012.664128
[Indexed for MEDLINE]

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