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Nat Rev Genet. 2012 Feb 14;13(3):204-14. doi: 10.1038/nrg3152.

Transcription as a source of genome instability.

Author information

1
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

Alterations in genome sequence and structure contribute to somatic disease, affect the fitness of subsequent generations and drive evolutionary processes. The crucial roles of highly accurate replication and efficient repair in maintaining overall genome integrity are well-known, but the more localized stability costs that are associated with transcribing DNA into RNA molecules are less appreciated. Here we review the diverse ways in which the essential process of transcription alters the underlying DNA template and thereby modifies the genetic landscape.

PMID:
22330764
PMCID:
PMC3376450
DOI:
10.1038/nrg3152
[Indexed for MEDLINE]
Free PMC Article

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