Format

Send to

Choose Destination
See comment in PubMed Commons below
Ophthalmic Surg Lasers Imaging. 2012 May-Jun;43(3):205-13. doi: 10.3928/15428877-20120209-01. Epub 2012 Feb 16.

In vivo confocal microscopic evaluation of corneal wound healing after femtosecond laser-assisted keratoplasty.

Author information

  • 1Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, Ann Arbor, MI 48105, USA. ronim@med.umich.edu

Abstract

BACKGROUND AND OBJECTIVE:

To evaluate corneal wound healing after femtosecond laser-assisted keratoplasty (FLAK) using in vivo confocal microscopy (IVCM).

PATIENTS AND METHODS:

Prospective, interventional, consecutive case series of 17 eyes after mushroom-shaped FLAK. IVCM was performed preoperatively and at 1, 3, 6, and 12 months postoperatively to assess wound healing.

RESULTS:

Mean keratocyte activation grade increased from preoperative levels to 1 month postoperatively in both the central (0.41 ± 0.62 to 1.73 ± 1.03) and peripheral (0.47 ± 0.52 to 1.57 ± 1.09) cornea, then gradually decreased through 12 months. Dendritic cells increased from preoperatively to 1 month postoperatively in both the central (0.71 ± 0.83 to 1.33 ± 0.98) and peripheral (0.79 ± 0.70 to 1.42 ± 0.90) cornea, then gradually decreased until 6 months postoperatively. Stromal reinnervation was 1 month postoperatively in 8 patients (50%). By 12 months, sub-epithelial nerves were observed centrally in 5 patients (45.5%).

CONCLUSION:

IVCM after FLAK shows an initial increase in keratocyte activation and dendritic cells that decrease over time. Corneal reinnervation is seen as early as 1 month postoperatively.

PMID:
22329795
PMCID:
PMC3535438
DOI:
10.3928/15428877-20120209-01
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for SLACK Incorporated. Icon for PubMed Central
    Loading ...
    Support Center