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Pediatr Dermatol. 2012 Sep-Oct;29(5):665-6. doi: 10.1111/j.1525-1470.2011.01641.x. Epub 2012 Feb 14.

Atypical granular cell tumor occurring in an individual with Noonan syndrome treated with growth hormone.

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Dermatology Service, Centre Hospitalier de Valence, Valence, France.


We report a large infiltrating atypical granular cell tumor in a child with Noonan syndrome. Even though granular cell tumors are rare in childhood, five cases have been reported in children with Noonan syndrome. This study compares these different cases and explores the possibility of activation of the granular cell by the Ras pathway.

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