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Chem Commun (Camb). 2012 Mar 21;48(24):2961-3. doi: 10.1039/c2cc16937a. Epub 2012 Feb 13.

Nanoparticles act as protein carriers during cellular internalization.

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1
School of Chemistry and Biochemistry and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.

Abstract

Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demonstrates the importance of nanoparticle-protein interactions in cellular applications.

PMID:
22328990
DOI:
10.1039/c2cc16937a
[Indexed for MEDLINE]
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