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J Bacteriol. 2012 Apr;194(8):2020-6. doi: 10.1128/JB.06243-11. Epub 2012 Feb 10.

The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT.

Author information

1
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. sunyc@ipbcams.ac.cn

Abstract

Yersinia pestis, which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a means to enhance transmission. Biofilm development is positively regulated by hmsT, encoding a diguanylate cyclase that synthesizes the bacterial second messenger cyclic-di-GMP. Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription of hmsT.

PMID:
22328676
PMCID:
PMC3318482
DOI:
10.1128/JB.06243-11
[Indexed for MEDLINE]
Free PMC Article
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