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Nat Med. 2012 Feb 12;18(3):382-4. doi: 10.1038/nm.2673.

Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.

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1
Foundation Medicine, Cambridge, Massachusetts, USA.

Abstract

Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma. Further screening of 561 lung adenocarcinomas identified 11 additional tumors with KIF5B-RET gene fusions (2.0%; 95% CI 0.8-3.1%). Cells expressing oncogenic KIF5B-RET are sensitive to multi-kinase inhibitors that inhibit RET.

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PMID:
22327622
PMCID:
PMC3916180
DOI:
10.1038/nm.2673
[Indexed for MEDLINE]
Free PMC Article

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