Send to

Choose Destination
See comment in PubMed Commons below
J Innate Immun. 2012;4(3):241-7. doi: 10.1159/000335029. Epub 2012 Feb 10.

Antimicrobial RNases in cutaneous defense.

Author information

Department of Dermatology, University Hospital Schleswig-Holstein, Kiel Campus, Kiel, Germany.


Antimicrobial proteins (AMP) are small endogenous proteins which are capable of rapidly inactivating microorganisms at low micro- and nanomolar concentrations. Their significance in host defense is reflected by their wide distribution in nature. Several AMP have been isolated from human skin, and there is increasing evidence that AMP may play an important role in cutaneous defense. One important human AMP class comprises several antimicrobial members of the RNase A superfamily. Of these, two members, RNase 7 and RNase 5, have been implicated in cutaneous defense. This review gives an overview about our current knowledge on the potential role of RNase 7 and RNase 5 in protecting human skin from infection.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center