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J Innate Immun. 2012;4(3):241-7. doi: 10.1159/000335029. Epub 2012 Feb 10.

Antimicrobial RNases in cutaneous defense.

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1
Department of Dermatology, University Hospital Schleswig-Holstein, Kiel Campus, Kiel, Germany.

Abstract

Antimicrobial proteins (AMP) are small endogenous proteins which are capable of rapidly inactivating microorganisms at low micro- and nanomolar concentrations. Their significance in host defense is reflected by their wide distribution in nature. Several AMP have been isolated from human skin, and there is increasing evidence that AMP may play an important role in cutaneous defense. One important human AMP class comprises several antimicrobial members of the RNase A superfamily. Of these, two members, RNase 7 and RNase 5, have been implicated in cutaneous defense. This review gives an overview about our current knowledge on the potential role of RNase 7 and RNase 5 in protecting human skin from infection.

PMID:
22327069
DOI:
10.1159/000335029
[Indexed for MEDLINE]
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