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Gene. 2012 Apr 15;497(2):340-3. doi: 10.1016/j.gene.2012.01.024. Epub 2012 Feb 3.

Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice.

Author information

1
Department of Pharmacotherapy, Hiroshima University, Hiroshima, Japan. b060720@hiroshima-u.ac.jp

Abstract

Saturated fatty acids, acting as ligands for toll-like receptor 4 (TLR4), induce inflammation and mediate the development of insulin resistance. Myeloid differentiation factor 88 (MyD88) is an adaptor protein for TLR4. Previously, we found MyD88-deficient mice fed a high-fat diet (HFD) exhibited a severe diabetic phenotype. Stearoyl-CoA Desaturase 1 (SCD1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and known as a risk factor of diabetes. In the present study, we found SCD1 was dramatically increased in HFD-fed MyD88-deficient mice liver. This finding showed the novel linkage between MyD88 and SCD1 in the development of diabetes mellitus.

PMID:
22326531
DOI:
10.1016/j.gene.2012.01.024
[Indexed for MEDLINE]

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