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Gastroenterology. 2012 May;142(5):1100-1101.e2. doi: 10.1053/j.gastro.2012.01.034. Epub 2012 Feb 8.

A high-fat diet is associated with endotoxemia that originates from the gut.

Author information

1
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10065, USA.

Abstract

Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome. Placing 8 healthy subjects on a Western-style diet for 1 month induced a 71% increase in plasma levels of endotoxin activity (endotoxemia), whereas a prudent-style diet reduced levels by 31%. The Western-style diet might, therefore, contribute to endotoxemia by causing changes in gastrointestinal barrier function or the composition of the microbiota. Endotoxemia might also develop in individuals with gastrointestinal barrier impairment. Therapeutic reagents that reduce endotoxemia might reduce systemic inflammation in patients with gastrointestinal diseases or metabolic syndrome.

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PMID:
22326433
PMCID:
PMC3978718
DOI:
10.1053/j.gastro.2012.01.034
[Indexed for MEDLINE]
Free PMC Article

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