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Fungal Genet Biol. 2012 Sep;49(9):677-8. doi: 10.1016/j.fgb.2012.01.008. Epub 2012 Feb 4.

Non-lytic expulsion/exocytosis of Candida albicans from macrophages.

Author information

1
Immunology and Infection, School of Medicine and Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, UK.

Abstract

Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C. albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells.

PMID:
22326419
PMCID:
PMC3430864
DOI:
10.1016/j.fgb.2012.01.008
[Indexed for MEDLINE]
Free PMC Article

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