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Bioorg Med Chem Lett. 2012 Mar 1;22(5):1940-3. doi: 10.1016/j.bmcl.2012.01.041. Epub 2012 Jan 25.

Aminopyrimidinone cdc7 kinase inhibitors.

Author information

1
Abbott Laboratories, 100 Abbott Park Rd., R47S AP10/307, Abbott Park, IL 60064-6101, USA. keith.w.woods@abbott.com

Abstract

We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K(i)) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds to inhibition of MCM2 phosphorylation.

PMID:
22326396
DOI:
10.1016/j.bmcl.2012.01.041
[Indexed for MEDLINE]

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