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Bioorg Med Chem Lett. 2012 Mar 1;22(5):1936-9. doi: 10.1016/j.bmcl.2012.01.045. Epub 2012 Jan 25.

Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.

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1
Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.

Abstract

A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.

PMID:
22325944
DOI:
10.1016/j.bmcl.2012.01.045
[Indexed for MEDLINE]
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