[Analysis of the initial efficacy of nedaplatin combined with megestrol in concurrent chemoradiotherapy for advanced cervical cancer]

Zhonghua Zhong Liu Za Zhi. 2011 Aug;33(8):629-31.
[Article in Chinese]

Abstract

Objective: To investigate the early efficacy of nedaplatin combined with megestrol in concurrent chemoradiotherapy for advanced cervical cancer.

Methods: Forty-two cases of cervical cancer (FIGO IIb to IVa) were divided randomly into two groups: radiotherapy alone (21 cases) and radiation plus chemotherapy (Nedaplatin) group. The same radiotherapy was given to the two groups. Patients of the RT + C group received nedaplatin 30 mg/m2 in intravenous drip infusion once weekly on day 1, for 4 to 5 weeks, and megestrol 160 mg orally every day during the radiation therapy.

Results: The early outcome: the complete remission rate was 81.0% and partial remission rate was 19.0% in the RT + C group, significantly better than the CR (38.1%) and PR (42.9%) in the RT group. The 1-year survival rates in the two groups were 100% (21/21) and 81.0% (17/21), respectively, with a significant difference between the two groups (P<0.05).

Conclusions: The combination of nedaplatin and megestrol with concurrent chemoradiotherapy can improve the early outcome of advanced cervical cancer, with somewhat increased but tolerable adverse effects.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adenocarcinoma* / drug therapy
  • Adenocarcinoma* / pathology
  • Adenocarcinoma* / radiotherapy
  • Adult
  • Alopecia / chemically induced
  • Anemia / chemically induced
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Brachytherapy
  • Chemoradiotherapy* / adverse effects
  • Diarrhea / chemically induced
  • Female
  • Follow-Up Studies
  • Humans
  • Iridium Radioisotopes / therapeutic use
  • Leukopenia / chemically induced
  • Megestrol / administration & dosage
  • Middle Aged
  • Neoplasm Staging
  • Organoplatinum Compounds / administration & dosage
  • Particle Accelerators
  • Radiotherapy, High-Energy
  • Remission Induction
  • Survival Rate
  • Thrombocytopenia / chemically induced
  • Uterine Cervical Neoplasms* / drug therapy
  • Uterine Cervical Neoplasms* / pathology
  • Uterine Cervical Neoplasms* / radiotherapy

Substances

  • Iridium Radioisotopes
  • Organoplatinum Compounds
  • nedaplatin
  • Megestrol