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J Pediatr. 2012 Jul;161(1):70-4.e1-2. doi: 10.1016/j.jpeds.2011.12.038. Epub 2012 Feb 10.

Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants.

Collaborators (249)

Caplan MS, Oh W, Vohr BR, Alksninis B, Stephens BE, Yatchmink Y, Burke R, Hensman AM, Leach TM, Leonard MR, Noel L, Vogt RA, Watson VE, Ventura S, Fanaroff AA, Wilson-Costello DE, Newman NS, Siner BS, Friedman HG, Schibler K, Donovan EF, Steichen JJ, Yolton K, Alexander B, Bridges K, Grisby C, Mersmann MW, Mincey HL, Hessling J, Gratton TL, Goldberg RN, Cotten C, Auten KJ, Fisher KA, Foy KA, Gustafson KE, Lohmeyer MB, Carlton DP, Adams-Chapman I, Carter S, Dinkin E, Hale EC, LaRossa MM, Smikle GV, Wright LL, McClure EM, Archer SW, Frantz ID 3rd, McGowan EC, MacKinnon BL, Nylen E, Furey A, Sibley C, Brussa A, Poindexter BB, Lemons JA, Dusick AM, Lytle C, Bohnke LG, Eaken G, Herron DE, Miller LC, Minnich HM, Richard L, Wilson LD, Hamer F, Poole W, Wallace D, Auman JO, Cunningham M, Hastings BK, McClure E, Huitema CM, Zaterka-Baxter KM, Van Meurs KP, Stevenson DK, Hintz SR, Ball M, Adams MM, Ahlfors CE, Baran JM, Bentley B, Bond LE, Brudos GK, Davis AS, DeAnda ME, DeBattista AM, Epcar JT, Fleisher BE, Ismael M, Kohn JG, Kuelper CG, Lee-Ancajas JC, Proud MS, Pyle RP, Sivakuma D, Stebbins RD, St John NH, Carlo WA, Ambalavanan N, Peralta-Carcelen M, Nelson KG, Bailey KJ, Biasini FJ, Chopko SA, Collins MV, Cosby SS, Moses MB, Phillips VA, Preskitt J, Rector RV, Whitley S, Finer NN, Vaucher YE, Rasmussen MR, Wozniak PR, Arnell K, Bridge R, Demetrio C, Fuller MG, Posin D, Rich W, Widness JA, Acarregui MJ, Johnson KJ, Eastman DL, Krutzfield NJ, Bauer CR, Duara S, Everett-Thomas R, Worth AM, Allison M, Diaz AN, Mathews EO, Hamlin-Smith K, Jean L, Calejo M, Eguaras SM, Hiriart-Fajardo S, Gideon YC, Stoerger A, Garcia A, Pierre H, Watterberg KL, Papile LA, Ohls RK, Lacy B, Lowe JR, Montman R, Phelps DL, Guillet R, Myers GJ, Reubens LJ, Burnell E, Rowan M, Johnson JB, Jensen RL, Kushner E, Merzbach J, Zwetsch L, Yost K, Korones SB, Bada HS, Hudson T, Williams M, Yolton K, Sánchez PJ, Laptook AR, Rosenfeld CR, Salhab WA, Broyles R, Heyne RJ, Adams SS, Twell C, Dooley C, Guzman A, Heyne E, Hickman JF, Leps MH, Madden LA, Miller NA, Morgan JS, Madison S, Hensley G, Vasil DM, Torres LE, Tyson JE, Kennedy KA, Akpa EG, Cluff PA, Harris BF, Franco CI, Lis AE, Martin S, McDavid GE, Tate PL, Simmons MC, Evans P, Alaniz NI, Bradt PJ, Dieterich S, Green C, Jimine M, Major-Kincade T, Morris BH, Poundstone M, Siddiki S, Simmons MC, Whitely LL, Wright SL, Faix RG, Yoder BA, Bodnar A, Steffens M, Burnett J, Jensen JJ, Osborne KA, Spencer C, Weaver-Lewis K, O'Shea T, Peters NJ, Chiu K, Allred DE, Goldstein DJ, Halfond R, Jackson BG, Peterson C, Waldrep EL, Morris MW, Hounshell GW, Johnson YR, Bara R, Driscoll D, Goldston L, Kennedy D, Muran G, Ehrenkranz RA, Jacob H, Cervone P, Gettner P, Close N, Gilliam W, Konstantino M, Poulsen J, Romano E, Taft J, Williams J, Butle C, Greisman S.

Author information

1
Department of Pediatrics, Wayne State University, Detroit, MI, USA.

Abstract

OBJECTIVE:

The study goal was to evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among extremely low birth weight (ELBW) infants.

STUDY DESIGN:

This is a retrospective analysis of ELBW (<1000 g) and <27 weeks' gestational age infants born in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network sites between January 2000 and June 2007. Infants were tracked until death or 18 to 22 months' corrected age. Infants who died between NICU discharge and the 18- to 22-month follow-up visit were classified as post-NICU discharge mortality (P-NDM). Association of maternal and infant risk factors with P-NDM was determined using logistic regression analysis. A prediction model with 6 significant predictors was developed and validated.

RESULTS:

There were 5364 infants who survived to NICU discharge; 557 (10%) infants were lost to follow-up, and 107 infants died following NICU discharge. P-NDM rate was 22.3 per 1000 ELBW infants. In the prediction model, African American race, unknown maternal health insurance, and hospital stay ≥ 120 days significantly increased risk, and maternal exposure to intrapartum antibiotics was associated with decreased risk of P-NDM.

CONCLUSION:

We identified African American race, unknown medical insurance, and prolonged NICU stay as risk factors associated with P-NDM among ELBW infants.

PMID:
22325187
PMCID:
PMC3366175
DOI:
10.1016/j.jpeds.2011.12.038
[Indexed for MEDLINE]
Free PMC Article

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