Format

Send to

Choose Destination
See comment in PubMed Commons below
J Korean Med Sci. 2012 Feb;27(2):221-4. doi: 10.3346/jkms.2012.27.2.221. Epub 2012 Jan 27.

Severe osteomyelitis as a complication of Tokyo-172 BCG vaccination.

Author information

1
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

The bacilli Calmette-Guérin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.

KEYWORDS:

Bacilli Calmette-Guérin Vaccination; Complication; Osteomyelitis

PMID:
22323874
PMCID:
PMC3271300
DOI:
10.3346/jkms.2012.27.2.221
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Korean Academy of Medical Sciences Icon for PubMed Central
    Loading ...
    Support Center