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Q Rev Biophys. 2012 May;45(2):147-207. doi: 10.1017/S0033583512000017. Epub 2012 Feb 10.

Biophysics of mitosis.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. richard.mcintosh@colorado.edu

Abstract

Mitosis is the process by which eukaryotic cells organize and segregate their chromosomes in preparation for cell division. It is accomplished by a cellular machine composed largely of microtubules (MTs) and their associated proteins. This article reviews literature on mitosis from a biophysical point of view, drawing attention to the assembly and motility processes required to do this complex job with precision. Work from both the recent and the older literature is integrated into a description of relevant biological events and the experiments that probe their mechanisms. Theoretical work on specific subprocesses is also reviewed. Our goal is to provide a document that will expose biophysicists to the fascination of this quite amazing process and provide them with a good background from which they can pursue their own research interests in the subject.

PMID:
22321376
PMCID:
PMC4433171
DOI:
10.1017/S0033583512000017
[Indexed for MEDLINE]
Free PMC Article

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