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Trends Cell Biol. 2012 Apr;22(4):193-200. doi: 10.1016/j.tcb.2012.01.003. Epub 2012 Feb 7.

Predicting division plane position and orientation.

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Institut Curie, UMR 144 CNRS/IC, 26 rue d'Ulm, 75248 Paris Cedex 05, France.


Predicting cellular behavior is a major challenge in cell and developmental biology. Since the late nineteenth century, empirical rules have been formulated to predict the position and orientation of mitotic cleavage planes in plant and animal cells. Here, we review the history of division plane orientation rules and discuss recent experimental and theoretical studies that refine these rules and provide mechanistic insights into how division can be predicted. We describe why some of these rules may better apply to certain cell types and developmental contexts and discuss how they could be integrated in the future to allow the prediction of division positioning in tissues.

[Indexed for MEDLINE]

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