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Adv Mater. 2012 Mar 15;24(11):1466-70. doi: 10.1002/adma.201103501. Epub 2012 Feb 9.

Density gradient multilayer polymerization for creating complex tissue.

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1
Biomedical Sciences Program, University of California at San Diego, La Jolla, 92093-0600, USA.

Abstract

An adaptable density gradient multilayer polymerization (DGMP) method facilitates simple fabrication of complex multicompartment scaffolds with structurally continuous interfaces. Solvent density liquid-liquid phase segregation compartmentalizes varied mechanical and chemical cues independently. Bulk photopolymerization produces stratified three-dimensional and two-dimensional matrices. Cells attach to patterned adhesion peptides on biomimetic 2D substrates.

PMID:
22318771
PMCID:
PMC3309044
DOI:
10.1002/adma.201103501
[Indexed for MEDLINE]
Free PMC Article
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