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Cell Biochem Funct. 2012 Jun;30(4):271-8. doi: 10.1002/cbf.2793. Epub 2012 Feb 7.

Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.

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Key Laboratory of Transcriptome and Proteome of Human Diseases Supported by Guangdong Province and the Ministry of China, Southern Medical University, Guangzhou, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.


Triptolide is a diterpenoid triepoxide derived from the traditional Chinese medical herb Tripterygium wilfordii. In the present study, we demonstrated that this phytochemical attenuated colon cancer growth in vitro and in vivo. Using a proteomic approach, we found that 14-3-3 epsilon, a cell cycle- and apoptosis-related protein, was altered in colon cancer cells treated with triptolide. In this regard, triptolide induced cleavage and perinuclear translocation of 14-3-3 epsilon. Taken together, our findings suggest that triptolide may merit investigation as a potential therapeutic agent for colon cancer, and its anticancer action may be associated with alteration of 14-3-3 epsilon.

[Indexed for MEDLINE]

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