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Semin Cancer Biol. 2012 Aug;22(4):282-8. doi: 10.1016/j.semcancer.2012.01.010. Epub 2012 Jan 31.

Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells.

Author information

1
Department of Internal Medicine, University of South Florida, Tampa, FL 33612, United States. snagaraj@health.usf.edu

Abstract

Myeloid derived suppressor cells play a critical role in T cell suppression in cancer. Here, we discuss the mechanisms of how MDSC suppress CD4(+) or CD8(+) T cells in an antigen dependent or non-dependent manner.

PMID:
22313876
PMCID:
PMC3349790
DOI:
10.1016/j.semcancer.2012.01.010
[Indexed for MEDLINE]
Free PMC Article

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